The Rogers Foundation announces a second landmark gift, building on its $130 million gift in 2014, to sustain the Ted Rogers Centre for Heart Research in perpetuity and bring the promise of precision cardiac health to patients across Canada and globally. In 2014, the...
Nearly 20 years ago, University of Toronto professor Paul Santerre and his team pioneered a new way of making medical implants that reduces the risk of blood clots and infections. Now, the technology is set to go global as it is acquired by Evonik, a multinational specialty chemicals firm that is now maintaining a presence in Toronto.
“This is a professor’s dream,” says Santerre, an investigator in the Ted Rogers Centre’s TBEP program. “It the best outcome for our startup: investment, sales and drawing a major company here to do product development.”
From catheters to artificial hips, implants are a critical
component of modern health care. But the surfaces of the materials from which they
are made can serve as a habitat for infectious bacteria. They can also trigger
the body’s natural responses, including life-threatening blood clots released
through a process known as thrombosis.
Modifying the surface
of materials to be implanted
Santerre’s technology works by modifying the surface of
materials designed to be implanted into the body. These modifications make it
harder for certain proteins — such as those that cause blood clots, whether
secreted by invading bacteria, blood platelets or blood cells — to stick to the
surface.
At the heart of the innovation is a series of short-chain
molecules, called oligomers. Like another famous non-stick material, Teflon,
the oligomers that Santerre conceived contain fluorine as part of their
chemical structure.
But whereas Teflon must be spray-coated onto a surface after
it’s made, Santerre’s additives can be mixed directly into molten plastic. As
the plastic cools, the oligomers migrate to the top few nanometres, creating a
non-stick surface without the need for an additional manufacturing steps.
In 2001, the additives were part of a suite of innovations
used to form the U of T spinoff company, Interface Biologics, Inc. (IBI), based
in downtown Toronto.
Innovation ecosystem in Toronto grows further
This week, IBI announced that its surface modification
division will be acquired by Evonik. Active in over 100 countries around the
world, Evonik has more than 32,000 employees who last year generated more than
€13.3 billion in sales.
The IBI team will support Evonik’s continuity of the
business under a two-year transition services agreement. Evonik is expected to
build on IBI’s expertise in surface modification by maintaining a presence in
Toronto
“Evonik was impressed not only by the IBI story, but by the
rich and growing innovation ecosystem across U of T, and Toronto more
generally,” says Santerre.
Santerre says that the new deal will take the technology to
larger markets faster than would have been possible with IBI. But he is even
more excited by what this means for the future of entrepreneurship and
commercialization at U of T.
“Evonik is now the second major multinational health technology company to want to live here,” he says. “They will likely catalyze many more to come.”
* This article has been slightly modified from its original source