Publications

This is an updated list of recently published studies by members of the Ted Rogers Centre for Heart Research.

 

November 2017

The need for heart failure advocacy in Canada

 

October 2017

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA Jr, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Nat Genet. 2017 Oct 9

 

September 2017

A local quality initiative to improve follow-up times for patients with heart failure

Schofield T,  Duero Posada J,  Foroutan F, Alba C, McDonald M, Linghorne M. 

Effects of slice orientation on reproducibility of sequential assessment of right ventricularvolumes and ejection fraction: short-axis vs transverse SSFP cine cardiovascular magneticresonance

D’Errico L, Lamacie M, Jimenez Juan L, Deva D, Wald R, Ley S, Hanneman K, Thavendiranathan P, Wintersperger B. J Cardiovasc Magn Reson. 2016 Sep 22;18(1):60

August 2017

Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering

Usprech J, Romero DA, Amon CH, Simmons CA. Acta Biomater. 2017 Aug;58:34-43
Zhang X, Bendeck M, Simmons C, Santerre J. Biomaterials. 2017 Aug 15;145:9-22

Hemocompatibility of degrading polymeric biomaterials: degradable polar hydrophobic ionic polyurethane versus poly(lactic-co-glycolic) acid

Brockman KS, Lai BFL, Kizhakkedathu JN, Santerre JP. Biomacromolecules. 2017 Aug 14;18(8):2296-2305

High-risk cardiac surgery as an alternative to transplant or mechanical support in patients with end-stage heart failure

Kawajiri H, Manlhiot C, Ross H, Delgado D, Billia F, McDonald M, Rao V. J Thorac Cardiovasc Surg. 2017 Aug;154(2):517-525

Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test

Lionel AC, Costain G, Monfared N, Walker S, Reuter MS, Hosseini SM, Thiruvahindrapuram B, Merico D, Jobling R, Nalpathamkalam T, Pellecchia G, Sung WWL, Wang Z, Bikangaga P, Boelman C, Carter MT, Cordeiro D, Cytrynbaum C, Dell SD, Dhir P, Dowling JJ, Heon E, Hewson S, Hiraki L, Inbar-Feigenberg M, Klatt R, Kronick J, Laxer RM, Licht C, MacDonald H, Mercimek-Andrews S, Mendoza-Londono R, Piscione T, Schneider R, Schulze A, Silverman E, Siriwardena K, Snead OC, Sondheimer N, Sutherland J, Vincent A, Wasserman JD, Weksberg R, Shuman C, Carew C, Szego MJ, Hayeems RZ, Basran R, Stavropoulos DJ, Ray PN, Bowdin S, Meyn MS, Cohn RD, Scherer SW, Marshall CR. Genet Med. 2017 Aug 3. doi: 10.1038/gim.2017.119.

Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer: a multi-centre observational study

Skitch A, Mital S, Mertens L, Liu P, Kantor P, Grosse-Wortmann L, Manlhiot C, Greenberg M, Nathan PC. BMC Cancer. 2017 Aug 3;17(1):519

 

July 2017

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1

Sivasubramaniyam T, Schroer S, Li A, Luk C, Shi S, Besla R, Dodington D, Metherel A, Kitson A, Brunt J, Lopes J, Wagner K, Bazinet R, Bendeck M, Robbins C, Woo M. JCI Insight. 2017 Jul 20;2(14)

Hypoxia-Induced Changes in the Fibroblast Secretome, Exosome, and Whole-Cell Proteome Using Cultured, Cardiac-Derived Cells Isolated from Neonatal Mice.

Cosme J, Guo H, Hadipour-Lakmehsari S, Emili A, Gramolini AO. J Proteome Res. 2017 Jul 6

June 2017

Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial

Ramroop R, Manase G, Lu D, Manase D, Chen S, Kim R, Lee T, Mahle WT, McHugh K, Mitchell M, Tristani-Firouzi M, Wechsler SB, Wilder NS, Zak V, Lafreniere-Roula M, Newburger JW, Gaynor JW, Russell MW, Mital SJ Thorac Cardiovasc Surg. 2017 Jun 24

Adverse cardiac events associated with incident opioid drug use among older adults with COPD

Vozoris NT, Wang X, Austin PC, Lee DS, Stephenson AL, O’Donnell DE, Gill SS, Rochon PA. Eur J Clin Pharmacol. 2017 Jun 29

Barriers to goals of care discussions with patients who have advanced heart failure: results of a multi-centre survey of hospital-based cardiology clinicians

You J, Aleksova N, Ducharme A, MacIver J, Mielniczuk L, Fowler R, Demers C, Clarke B, Parent M, Toma M, Strachan P, Farand P, Isaac D, Zieroth S, Swinton M, Jiang X, Day A, Heyland D, Ross H. J Card Fail. 2017 Jun 22

Candidate gene resequencing in a large bicuspid aortic valve-associated thoracic aortic aneurysm cohort: SMAD6 as an important contributor

Gillis E, Kumar AA, Luyckx I, Preuss C, Cannaerts E, van de Beek G, Wieschendorf B, Alaerts M, Bolar N, Vandeweyer G, Meester J, Wünnemann F, Gould RA, Zhurayev R, Zerbino D, Mohamed SA, Mital S, Mertens L, Björck HM, Franco-Cereceda A, McCallion AS, Van Laer L, Verhagen JMA, van de Laar IMBH, Wessels MW, Messas E, Goudot G, Nemcikova M, Krebsova A, Kempers M, Salemink S, Duijnhouwer T, Jeunemaitre X, Albuisson J, Eriksson P, Andelfinger G, Dietz HC, Verstraeten A, Loeys BL; Mibava Leducq Consortium. Front Physiol. 2017 Jun 13;8:400

Coordinating cell movements in vivo: junctional and cytoskeletal dynamics lead the way

Hunter MV, Fernandez-Gonzalez RCurr Opin Cell Biol. 2017 Jun 13;48:54-62

Percutaneous left atrial decompression in adults with refractory cardiogenic shock supported with veno-arterial extracorporeal membrane oxygenation

Alhussein M, Osten M, Horlick E, Ross H, Fan E, Rao V, Billia F. J Card Surg. 2017 Jun;32(6):396-401

Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation

Goldberg DJ, Zak V, Goldstein BH, Chen S, Hamstra MS, Radojewski EA, Maunsell E, Mital S, Menon SC, Schumacher KR, Payne RM, Stylianou M, Kaltman JR, deVries TM, Yeager JL, Paridon SM; Pediatric Heart Network Investigators. Am Heart J. 2017 Jun;188:42-52

Use of clinical exome sequencing in isolated congenital heart disease

Zahavich L, Bowdin S, Mital S. Circ Cardiovasc Genet. 2017 Jun;10(3)

 

May 2017

Associations between short or long length of stay and 30-Day readmission and mortality in hospitalized patients with heart failure

Sud M, Yu B, Wijeysundera HC, Austin PC, Ko DT, Braga J, Cram P, Spertus JA, Domanski M, Lee DS. JACC Heart Fail. 2017 May 10

Cell and tissue scale forces coregulate Fgfr2-dependent tetrads and rosettes in the mouse embryo

Wen J, Tao H, Lau K, Liu H, Simmons CA, Sun Y, Hopyan S. Biophys J. 2017 May 23;112(10):2209-2218

Closing the care gap: A primer on quality improvement for heart failure clinicians

Moayedi Y, Schofield T, Etchells E, Silver S, Kobulnik J, McQuillan R, Bell C, Linghorne M, Ross H. Circ Heart Fail. 2017 May;10(5). pii: e003722

Effect of experience and training on the concordance and precision of strain measurements

Negishi T, Negishi K, Thavendiranathan P, Cho G, Popescu B, Vinereanu D, Kurosawa K, Penicka M, Marwick T; SUCCOUR Investigators. JACC Cardiovasc Imaging. 2017 May;10(5):518-522.

Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment.

Zhang X, Battiston KG, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2017 May;54:81-94.

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958

 

April 2017

Advances in heart failure: a review of biomarkers, emerging pharmacological therapies, durable mechanical support and telemonitoring

Moayedi Y, Ross HJ. Clin Sci (Lond). 2017 Apr 1;131(7):553-566

Automated cell tracking identifies mechanically oriented cell divisions during Drosophila axis elongation

Wang MF, Hunter MV, Wang G, McFaul C, Yip CM, Fernandez-Gonzalez R. Development. 2017 Apr 1;144(7):1350-1361

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

Kroetsch J, Levy A, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov S, Backx P, Heximer S, Bolz S.  Nat Commun. 2017 Apr 5;8:14805

Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease

Alibhai F, LaMarre J, Reitz C, Tsimakouridze E, Kroetsch J, Bolz S, Shulman A, Steinberg S, Burris T, Oudit G, Martino T. J Mol Cell Cardiol. 2017 Apr;105:24-37

NASA model of “Threat and Error” in pediatric cardiac surgery: patterns of error chains

Hickey E, Pham-Hung E, Nosikova Y, Halvorsen F, Gritti M, Schwartz S, Caldarone CA, Van Arsdell GAnn Thorac Surg. 2017 Apr;103(4):1300-1307

Shape of my heart: Cell-cell adhesion and cytoskeletal dynamics during Drosophila cardiac morphogenesis

McFaul CM, Fernandez-Gonzalez R. Exp Cell Res. 2017 Apr 5. pii: S0014-4827(17)30184-2

Short length of stay after elective transfemoral transcatheter aortic valve replacement is not associated with increased early or late readmission risk

Sud M, Qui F, Austin PC, Ko DT, Wood D, Czarnecki A, Patel V, Lee DS, Wijeysundera HC. J Am Heart Assoc. 2017 Apr 24

Tension (re)builds: Biophysical mechanisms of embryonic wound repair

Zulueta-Coarasa T, Fernandez-Gonzalez R. Mech Dev. 2017 Apr;144(Pt A):43-52

Urinary adenosine excretion in type 1 diabetes

Rajasekeran H, Lytvyn Y, Bozovic A, Lovshin J, Diamandis E, Cattran D, Husain M, Perkins BA, Advani A, Reich HN, Kulasingam V, Cherney DZ. Am J Physiol Renal Physiol. 2017 Apr 5:ajprenal.00043.2017

 

March 2017

Cell-cell and cell-ECM adhesions cooperate to organize actomyosin networks and maintain force transmission during Dorsal Closure

Goodwin K, Lostchuck EE, Cramb KM, Zulueta-Coarasa T, Fernandez-Gonzalez R, Tanentzapf G. Mol Biol Cell. 2017 Mar 22. pii: mbc.E17-01-0033.

Clinical genetic testing in pediatric cardiomyopathy: Is bigger better?

Ouellette A, Mathew J, Manickaraj A, Manase G, Zahavich L, Wilson J, George K, Benson L, Bowdin S, Mital S. Clin Genet. 2017 Mar 30

Could MRI be used to image kidney fibrosis? A review of recent advances and remaining barriers

Leung G, Kirpalani A, Szeto S, Deeb M, Foltz W, Simmons C, Yuen D. Clin J Am Soc Nephrol. 2017 Mar 15

Interventions for preventing cardiomyopathy due to anthracyclines: a Bayesian network meta-analysis

Abdel-Qadir H, Ong G, Fazelzad R, Amir E, Lee D, Thavendiranathan P, Tomlinson G. Ann Oncol. 2017 Mar 1;28(3):628-633

Left ventricular dysfunction with trastuzumab therapy: Is primary prevention the best option?

Thavendiranathan P, Amir E. J Clin Oncol. 2017 Mar 10;35(8):820-825

Left ventricular function in children and adolescents with arrhythmogenic right ventricular cardiomyopathy

Chungsomprasong P, Hamilton R, Luining W, Fatah M, Yoo S, Grosse-Wortmann L. Am J Cardiol. 2017 Mar 1;119(5):778-784

Measuring quality of life in advanced heart failure

MacIver J, Wentlandt K, Ross H. Curr Opin Support Palliat Care. 2017 Mar;11(1):12-16

Myosin II promotes the anisotropic loss of the apical domain during Drosophila neuroblast ingression

Simões S, Oh Y, Wang MF, Fernandez-Gonzalez R, Tepass U. J Cell Biol. 2017 Mar 31. pii: jcb.201608038.

Perspective on precision medicine in paediatric heart failure

Fridman M, Mital S. Clin Sci (Lond). 2017 Mar 1;131(6):439-448

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

Durgin B, Cherepanova O, Gomez D, Karaoli T, Alencar G, Butcher J, Zhou Y, Bendeck M, Isakson B, Owens G, Connelly J. Am J Physiol Heart Circ Physiol. 2017 Mar 10

 

February 2017

The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction.

Nayor M, Larson MG, Wang N, Santhanakrishnan R, Lee DS, Tsao CW, Cheng S, Benjamin EJ, Vasan RS, Levy D, Fox CS, Ho JE. Eur J Heart Fail. 2017 Feb 20

Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion.

Mofid A, Newman NS, Lee PJ, Abbasi C, Matkar PN, Rudenko D, Kuliszewski MA, Chen HH, Afrasiabi K, Tsoporis JN, Gramolini AO, Connelly KA, Parker TG, Leong-Poi H. J Am Heart Assoc. 2017 Feb 7;6(2). pii: e004738.

The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1

Dadson K, Hauck L, Hao Z, Grothe D, Rao V, Mak T, Billia F. Sci Rep. 2017 Feb 2;7:41490

Hands-on surgical training of congenital heart surgery using 3-dimensional print models

Yoo SJ, Spray T, Austin EH 3rd, Yun TJ, van Arsdell GS. J Thorac Cardiovasc Surg. 2017 Feb 9. pii: S0022-5223(17)30184-8

Interleukin-1β is a key biomarker and mediator of inflammatory vascular calcification

Shobeiri N, Bendeck M. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):179-180

Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment

Zhang X, Battiston KG, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2017 Feb 24. pii: S1742-7061(17)30143-5.

Geometry and growth of the reconstructed aorta in patients with hypoplastic left heart syndrome and variants

Haller C, Chetan D, Saedi A, Parker R, Van Arsdell GS, Honjo O. J Thorac Cardiovasc Surg. 2017 Feb 14. pii: S0022-5223(17)30222-2

Management of pregnancy in patients with complex congenital heart disease: A scientific statement for healthcare professionals from the American Heart Association

Canobbio MM, Warnes CA, Aboulhosn J, Connolly HM, Khanna A, Koos BJ, Mital S, Rose C, Silversides C, Stout K. Circulation. 2017 Feb 21;135(8):e50-e87

Mechanically assisted bidirectional cavopulmonary shunt in neonates and infants: An acute human pilot study

Honjo O, Merklinger SL, Poe JB, Guerguerian AM, Zhang H, Taylor KL, Van Arsdell GS. J Thorac Cardiovasc Surg. 2017 Feb;153(2):441-447

p53 regulates the cardiac transcriptome

Mak T, Hauck L, Grothe D, Billia F. Proc Natl Acad Sci U S A. 2017 Feb 13. pii: 201621436.

Prognostic impact of SPECT-MPI after renal transplantation.

Abuzeid W, Iwanochko RM, Wang X, Kim SJ, Husain M, Lee DS. J Nucl Cardiol. 2017 Feb;24(1):295-303.

Tension regulates myosin dynamics during Drosophila embryonic wound repair.

Kobb A, Zulueta-Coarasa T, Fernandez-Gonzalez R. J Cell Sci. 2017 Feb 15;130(4):689-696

Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy

Galant, N, Westermark P, Higaki J, Chakrabartty A. 

Ventricular thrombosis post-venoarterial extracorporeal membrane oxygenation

Alhussein M, Moayedi Y, Posada J, Ross H, Hickey E, Rao V, Billia F. Circ Heart Fail. 2017 Feb;10(2). pii: e003757

 

January 2017

A population-based study of cardiovascular mortality following early-stage breast cancer

Abdel-Qadir H, Austin P, Lee D, Amir E, Tu J, Thavendiranathan P, Fung K, Anderson G. JAMA Cardiol. 2017 Jan 1;2(1):88-93

Re-evaluating modality of cardiopulmonary exercise testing in patients with heart failure and resynchronization therapy: relevance of heart rate-adaptive pacing

Goldraich L, Ross H, Foroutan F, Walker M, Braga J, McDonald MA. J Card Fail. 2017 Jan 20

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2016 citations

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Select 2015 citations