Researchers at the Ted Rogers Centre for Heart Research have developed an innovative approach to better understanding the complex signaling mechanisms underlying heart failure. A recent publication in the Proceedings of the National Academy of Sciences (PNAS) offers...
Select 2015 studies by team members
December
De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies
Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. Science. 2015 Dec 4;350(6265):1262-6
November
Ireland RG, Simmons CA. Stem Cells. 2015 Nov;33(11):3187-96
October
Emerging trends in heart valve engineering: part IV. Computational modeling and experimental studies
Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Hamed Alavi S, Tranquillo R, Dasi LP, Simmons CA, Jane Grande-Allen K, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Ann Biomed Eng. 2015 Oct;43(10):2314-33
Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation.
Burchill LJ, Redington AN, Silversides CK, Ross HJ, Jimenez-Juan L, Mital S, Oechslin EN, Dragulescu A, Slorach C, Mertens L, Wald RM. Int J Cardiol. 2015 Oct 15;197:209-15
September
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function
Sharma P, Abbasi C, Lazic S, Teng A, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann W, Hamilton R, Sun Y, Liu P, Keller G, Stagljar I, Scott I, Kislinger T, Gramolini A. Nat Commun. 2015 Sep 25;6:8391
Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation
Battiston KG, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2015 Sep;24:74-86
Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype.
Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2015 Sep;24:35-43
July
Study of the influence of actin-binding proteins using linear analyses of cell deformability
Plaza GR, Uyeda TQ, Mirzaei Z, Simmons CA. Soft Matter. 2015 Jul 21;11(27):5435-46
June
Cardioprotective signature of short-term caloric restriction
Noyan H, El-Mounayri O, Isserlin R, Arab S, Momen A, Cheng H, Wu J, Afroze T, Li R, Fish J, Bader G, Husain M. PLoS One. 2015 Jun 22;10(6):e0130658
Metformin increases degradation of phospholamban via autophagy in cardiomyocytes
Teng A, Miyake T, Yokoe S, Zhang L, Rezende L, Sharma P, MacLennan D, Liu P, Gramolini A. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7165-70
May
Congenital heart disease in the older adult: a scientific statement from the American Heart Association.
Bhatt AB, Foster E, Kuehl K, Alpert J, Brabeck S, Crumb S, Davidson WR Jr, Earing MG, Ghoshhajra BB, Karamlou T, Mital S, Ting J, Tseng ZH; American Heart Association Council on Clinical Cardiology. Circulation. 2015 May 26;131(21):1884-931
April
Emerging trends in heart valve engineering: Part I. Solutions for future.
Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S. Ann Biomed Eng. 2015 Apr;43(4):833-43
Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement
Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo R, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MR, Falahatpisheh A, Griffith B, Baaijens F, Little SH, Canic S. Ann Biomed Eng. 2015 Apr;43(4):844-57
Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.
Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MR, Baaijens F, Canic S, Little SH. Ann Biomed Eng. 2015 Apr;43(4):858-70