Ian Scott is SickKids senior scientist in developmental and stem cell biology, and associate professor at U of T’s department of molecular genetics. His team focuses on using the genetic and imaging tools available in the zebrafish embryo to study the earliest molecular and cellular events associated with heart development.
As the genetic pathways that regulate heart formation are highly conserved across animal species, they are able to use the zebrafish embryo to model human congenital heart defects and heart failure. A major interest is exploring how the regenerative capacity of the zebrafish heart can be exploited to repair the damaged human heart.
Ultimately, they hope to use these models to interrogate novel therapeutic approaches.