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HDAX Therapeutics Announced as Winner of ECHO PITCH 2023

HDAX Therapeutics Announced as Winner of ECHO PITCH 2023

Nov 10, 2023

An innovative cardiovascular start-up, HDAX Therapeutics, is the latest company to win $250,000 in funding following another year of the Ted Rogers Centre for Heart Research’s Entrepreneurship for Cardiovascular Health Opportunities (ECHO) program. The ECHO program...

Ted Rogers Centre for Heart Research Wins Big at Vascular 2023

Ted Rogers Centre for Heart Research Wins Big at Vascular 2023

Nov 10, 2023

Several members of the Ted Rogers Centre for Heart Research (TRCHR) participated in Vascular 2023, a five-day conference held in Montreal from October 25-29. The conference is a hallmark event organized by several Canadian specialist and research organizations,...

Heart Failure Symposium 2023

3D models of heart failure… stiffened hearts in diabetes…. saving infant lives

Heart Failure Symposium 2023

After a heart attack, this peptide protects the heart from further injury

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Select 2015 studies by team members

December

De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies 

Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA Jr, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. Science. 2015 Dec 4;350(6265):1262-6

November

Human pluripotent stem cell mechanobiology: manipulating the biophysical microenvironment for regenerative medicine and tissue engineering applications

Ireland RG, Simmons CA. Stem Cells. 2015 Nov;33(11):3187-96

 

October

Emerging trends in heart valve engineering: part IV. Computational modeling and experimental studies

Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Hamed Alavi S, Tranquillo R, Dasi LP, Simmons CA, Jane Grande-Allen K, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Ann Biomed Eng. 2015 Oct;43(10):2314-33

Renin-angiotensin-aldosterone system genotype and serum BNP in a contemporary cohort of adults late after Fontan palliation.

Burchill LJ, Redington AN, Silversides CK, Ross HJ, Jimenez-Juan L, Mital S, Oechslin EN, Dragulescu A, Slorach C, Mertens L, Wald RM. Int J Cardiol. 2015 Oct 15;197:209-15

 

September

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

Sharma P, Abbasi C, Lazic S, Teng A, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann W, Hamilton R, Sun Y, Liu P, Keller G, Stagljar I, Scott I, Kislinger T, Gramolini A. Nat Commun. 2015 Sep 25;6:8391

Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation

Battiston KG, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2015 Sep;24:74-86

Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype.

Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Acta Biomater. 2015 Sep;24:35-43

 

July

Study of the influence of actin-binding proteins using linear analyses of cell deformability

Plaza GR, Uyeda TQ, Mirzaei Z, Simmons CA. Soft Matter. 2015 Jul 21;11(27):5435-46

 

June

Cardioprotective signature of short-term caloric restriction

Noyan H, El-Mounayri O, Isserlin R, Arab S, Momen A, Cheng H, Wu J, Afroze T, Li R, Fish J, Bader G, Husain M. PLoS One. 2015 Jun 22;10(6):e0130658

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes

Teng A, Miyake T, Yokoe S, Zhang L, Rezende L, Sharma P, MacLennan D, Liu P, Gramolini A. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7165-70

 

May

Congenital heart disease in the older adult: a scientific statement from the American Heart Association.

Bhatt AB, Foster E, Kuehl K, Alpert J, Brabeck S, Crumb S, Davidson WR Jr, Earing MG, Ghoshhajra BB, Karamlou T, Mital S, Ting J, Tseng ZH; American Heart Association Council on Clinical Cardiology. Circulation. 2015 May 26;131(21):1884-931

 

April

Emerging trends in heart valve engineering: Part I. Solutions for future.

Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S. Ann Biomed Eng. 2015 Apr;43(4):833-43

Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement

Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo R, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MR, Falahatpisheh A, Griffith B, Baaijens F, Little SH, Canic S. Ann Biomed Eng. 2015 Apr;43(4):844-57

Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.

Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MR, Baaijens F, Canic S, Little SH. Ann Biomed Eng. 2015 Apr;43(4):858-70

 

February

Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy

Reddy S, Fung A, Manlhiot C, Tierney ES, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital S.  Pediatr Res. 2015 Feb;77(2):363-9

Exome sequencing identifies rare variants in multiple genes in atrioventricular septal defect

D’Alessandro LC, Al Turki S, Manickaraj AK, Manase D, Mulder BJ, Bergin L, Rosenberg HC, Mondal T, Gordon E, Lougheed J, Smythe J, Devriendt K, Bhattacharya S, Watkins H, Bentham J, Bowdin S, Hurles ME, Mital S. Genet Med. 2016 Feb;18(2):189-98